Acetylcholine: Neurotransmitter at neuromuscular junctions, at autonomic ganglia, in the central nervous system and at postganglionic parasympathetic nerve endings
Acetylcholinesterase: Enzyme found in red blood cells, at neuromuscular junctions, parasympathetic effector sites, autonomic ganglia and in the central nervous system. Catalyses the breakdown of acetylcholine to acetic acid and choline
AChE: Acetylcholinesterase
Aging: In the context of nerve agents, a process of monodealkylation of the nerve agentacetylcholinesterase complex which renders the complex unreactivatable, either spontaneously or by pyridinium oximes Amyl nitrite Methaemoglobin-generating cyanide antidote. Can be inhaled
Atropine: Compound that blocks muscarinic acetylcholine receptors. Use produces dilation of the pupils and an increased heart rate. It is used in nerve agent poisoning to counteract the effects of increased amounts of acetylcholine that result from inhibition of acetylcholinesterase
Avizafone: A soluble prodrug of diazepam that is compatible for IM injection with atropine and pralidoxime mesilate and is included in some autoinjection devices such as the L4A1 ComboPen
AVPU: The AVPU scale allows rapid assessment of a casualty's state of consciousness. (Alert responds to Voice, responds to Pain, Unresponsive)
Cyclosarin: A liquid nerve agent of moderate volatility (cyclohexyl methylphosphonofluoridate). GF.
Dexamethasone: A synthetic steroid drug
Diazepam: Widely used sedative compound of the benzodiazepine group of drugs.
Dicobalt edetate: An EDTA chelate of cobalt ions. The commercial preparation contains free cobalt ions.
4-Dimethylaminophenol: A methaemoglobin-generating cyanide antidote
DMAP: 4-Dimethylaminophenol
DOX: Doxycylcine: an antibiotic
EDTA: Ethylenediamine tetra-acetic acid. Used as disodium EDTA, a chelating agent. This agent binds divalent metals such as calcium or cobalt.
ETYA: 5,8,11,14-eicosatetrayanoic acid. A substrate analogue used to reduce production of prostaglandins
Frusemide: A diuretic drug
GA: Tabun, ethyl N-dimethylphosphorocyanidate
GB: Sarin, isopropyl methylphosphonofluoridate
GD: Soman, pinacolyl methylphosphonofluoridate
GF: Cyclosarin, cyclohexyl methylphosphonylfluoridate
GSH: Glutathione. A natural antioxidant found in the body
HCN: Hydrogen cyanide
HI-6: A pyridinium oxime (asoxime chloride)
Hydrogen cyanide: Liquid or gas that blocks electron transport and thereby oxidative metabolism
Hydroxocobalamin: Vitamin B12a, a cyanide antidote. It consists of cobalt at the centre of a corrin structure and a nucleotide
Methaemoglobin: Haemoglobin contains iron in the divalent, reduced, ferrous state. Oxidation to the ferric (trivalent) form produces methaemoglobin. Methaemoglobin does not reversibly bind to oxygen but does bind to cyanide ions to form cyanmethaemoglobin
Mustard gas: Dichlordiethylene sulphide. Sulphur mustard. A vesicant widely used in World War I. A liquid at room temperature
NAC: N-acetylcysteine: a synthetic antioxidant drug
Nerve agents: Organophosphorus compounds of great toxicity, developed as chemical warfare agents Obidoxime A pyridinium oxime
Oximes: Pyridinium oximes are compounds that increase the rate of dissociation of an organophosphorus compound from acetylcholinesterase. Pralidoxime mesilate, obidoxime and HI-6 are pyridinium oximes. Oximes comprise a very large group of compounds, with diverse properties but pyridinium oximes, in terms of the treatment of organophosphate compounds are frequently simply referred to as oximes.
Pralidoxime mesilate (P2S): A pyridinium oxime
Prostaglandins: Large series of physiologically active compounds derived from unsaturated long chain fatty acids. These compounds play a part in inflammatory reactions in the body/ Production is inhibited by the antiinflammatory drug aspirin Pyridinium oximes These are compounds that increase the rate of dissociation of an organophosphorus compound from acetylcholinesterase.
Pyridostigmine: A carbamate drug that reversibly inhibits acetylchloinesterase
RADS: Reactive airways dysfunction syndrome. A syndrome produced by exposure to high concentrations of gases such as chlorine and characterised by an enhanced bronchoconstrictor response to airway irritants.
Sarin: A volatile liquid nerve agent, chemical name isopropyl methylphosphonofluoridate.
Sodium nitrite: Methemoglobin generating cyanide antidote
Sodium thiosulfate: Cyanide antidote that acts as a co-factor in the conversion of cyanide to the less toxic thiocyanate ion
Soman: A liquid nerve agent of moderate volatility. Chemical name pinacolyl methylphosphonofluoridate. Sulphur mustard Mustard gas
Symblepheron: Adhesions between the conjunctiva lining the eyelids (palpebral conjunctiva) and that covering the white of the eye (bulbar conjunctiva). Management includes gentle breaking down of adhesions by means of a glass rod or insertion of a ring to prevent adhesions forming.
Tabun: Nerve agent produced in Germany in the late 1930's: liquid of moderate volatility. Chemical name: ethyl N-dimethylphosphorocyanidate
Uveitis: Inflammation of the middle or uveal coat of the eye. The area comprises the iris, the ciliary body and the very vascular choroid that supports the retina
Vesicant: Substance that causes blistering of the skin.
VX: This nerve agent has no common name. A liquid of low volatility with the chemical name o-ethyl-s-[2(diisopropylamino)ethyl] methylphosphonthioate.
